Latest on Lupus Clinical Trials

Clinical trials help to answer the question, “Will this drug help people and be safe to take?”

At any given time, there are thousands of clinical trials going on. And finally, there are increasing numbers of lupus clinical trials.

Clinical trials are critical in the search for a better life for people with lupus.

Could You Be Part of the Solution?

Find out on our special website, LupusTrials.org.

What Are They Showing?

See the latest in results of clinical trials as they are reported in medical journals on the U.S. National Library of Medicine’s vast database of biomedical articles (PubMed). Some interesting ones from recent months include:

Successful treatment of shrinking lung syndrome with rituximab in a patient with systemic lupus erythematosus.
J Clin Rheumatol. 2010 Mar;16(2):68-70.

Re-evaluation of biologic therapies in systemic lupus erythematosus.
Curr Opin Rheumatol. 2010 Feb 19.

High dose cyclophosphamide versus monthly intravenous cyclophosphamide for systemic lupus erythematosus.
Arthritis Rheum. 2010 Jan 29.

Cyclophosphamide and Lupus Nephritis: When, How, For How Long?
Clin Rev Allergy Immunol. 2010 Jan 28

Efficacy of cognitive behavioural therapy for the treatment of chronic stress in patients with lupus erythematosus: a randomized controlled trial.
Psychother Psychosom. 2010;79(2):107-15.

The BILAG multi-centre open randomized controlled trial comparing ciclosporin vs azathioprine in patients with severe SLE.
Rheumatology (Oxford). 2010 Apr;49(4):723-32.

Nonrenal disease activity following mycophenolate mofetil or intravenous cyclophosphamide as induction treatment for lupus nephritis: findings in a multicenter, prospective, randomized, open-label, parallel-group clinical trial.
Arthritis Rheum. 2010 Jan;62(1):211-21.

Efficacy and safety of rituximab in moderately-to-severely active systemic lupus erythematosus: the randomized, double-blind, phase II/III systemic lupus erythematosus evaluation of rituximab trial.
Arthritis Rheum. 2010 Jan;62(1):222-33.

Effect of long-term belimumab treatment on B cells in systemic lupus erythematosus: extension of a phase II, double-blind, placebo-controlled, dose-ranging study.
Arthritis Rheum. 2010 Jan;62(1):201-10.

Negative relationship between expression of glucocorticoid receptor alpha and disease activity: glucocorticoid treatment of patients with systemic lupus erythematosus.
J Rheumatol. 2010 Feb;37(2):316-21.

Biologics as treatment for systemic lupus: great efforts, sobering results, new challenges.
Curr Drug Discov Technol. 2009 Dec;6(4):252-5.

Experience with mycophenolate mofetil as maintenance therapy in five pediatric patients with severe systemic lupus erythematosus.
Klin Padiatr. 2009 Dec;221(7):425-9.

Antiphospholipid antibody syndrome.
Hematology Am Soc Hematol Educ Program. 2009:233-9.

Management of young patients with lupus nephritis using tacrolimus administered as a single daily dose.
Clin Nephrol. 2009 Dec;72(6):430-6.

Baseline autoantibody profiles predict normalization of complement and anti-dsDNA autoantibody levels following Rituximab treatment in systemic lupus erythematosus.
Lupus. 2010 Feb;19(2):146-57. Epub 2009 Nov 27.

Combination therapy with steroids and mizoribine in juvenile SLE: a randomized controlled trial.
Pediatr Nephrol. 2010 May;25(5):877-82.

Vaccination, atherosclerosis and systemic lupus erythematosus.
Carvalho JF, Pereira RM, Shoenfeld Y.
Lupus. 2009 Nov;18(13):1209-12.

Adverse cutaneous reactions induced by TNF-alpha antagonist therapy.
South Med J. 2009 Nov;102(11):1133-40.

Effects of dehydroepiandrosterone on fatigue and well-being in women with quiescent systemic lupus erythematosus. A randomized controlled trial.
Ann Rheum Dis. 2009 Oct 22.

What's new in paediatric SLE?
Best Pract Res Clin Rheumatol. 2009 Oct;23(5):699-708.

Demystifying neuropsychiatric lupus--is it possible?
Bull NYU Hosp Jt Dis. 2009;67(3):276-80.

Clinical trials for lupus--are we there yet?
Bull NYU Hosp Jt Dis. 2009;67(3):267-70.

Prevalence of flare and influence of demographic and serologic factors on flare risk in systemic lupus erythematosus: a prospective study.
J Rheumatol. 2009 Nov;36(11):2476-80.

Drugs for discoid lupus erythematosus.
Cochrane Database Syst Rev. 2009 Oct 7;(4):CD002954.

Very long-term outcome of pure lupus membranous nephropathy treated with glucocorticoid and azathioprine.
Lupus. 2009 Oct;18(12):1091-5.PMID: 19762384

Effects of a 3-month course of rosuvastatin in patients with systemic lupus erythematosus.
Ann Rheum Dis. 2009 Oct;68(10):1654.

Clinical assessment of tacrolimus therapy in lupus nephritis: one-year follow-up study in a single center.
Nephron Clin Pract. 2009;113(4):c330-6.

Trial watch: BLYS-targeted antibody shows promise in Phase III SLE trial.
Nat Rev Drug Discov. 2009 Sep;8(9):688.

Novel evidence-based systemic lupus erythematosus responder index.
Arthritis Rheum. 2009 Sep 15;61(9):1143-51.

A phase II, randomized, double-blind, placebo-controlled, dose-ranging study of belimumab in patients with active systemic lupus erythematosus.
Arthritis Rheum. 2009 Sep 15;61(9):1168-78.

Rituximab and lupus: good in real life, bad in controlled trials. Comment on the article by Lu et al.
Arthritis Rheum. 2009 Sep 15;61(9):1281-2.

Efficacy and safety of tacrolimus for lupus nephritis: a placebo-controlled double-blind multicenter study.
Mod Rheumatol. 2009;19(6):606-15.

A randomized controlled trial of R-salbutamol for topical treatment of discoid lupus erythematosus.
Br J Dermatol. 2009 Dec;161(6):1365-70.

The Euro-Lupus Nephritis Trial: the development of the sequential treatment protocol.
Lupus. 2009 Sep;18(10):875-7

B cell depletion in lupus and Sjögren's syndrome: an update.
Curr Opin Rheumatol. 2009 Sep;21(5):483-8.

Safety of contraceptive method use among women with systemic lupus erythematosus: a systematic review.
Obstet Gynecol. 2009 Aug;114(2 Pt 1):341-53.

Flow cytometry analysis of glucocorticoid receptor expression and binding in steroid-sensitive and steroid-resistant patients with systemic lupus erythematosus.
Arthritis Res Ther. 2009;11(4):R108. Epub 2009 Jul 14.

Evaluation of the internet for finding persons with undiagnosed rheumatoid arthritis and systemic lupus erythematosus.
J Clin Rheumatol. 2009 Aug;15(5):218-22.

Antiproteinuric effect of angiotensin-converting enzyme inhibitors and an angiotensin II receptor blocker in patients with lupus nephritis.
J Int Med Res. 2009 May-Jun;37(3):892-8.

Azathioprine, the Cinderella in the treatment of lupus nephritis.
Nephrol Dial Transplant. 2009

Abetimus sodium: a medication for the prevention of lupus nephritis flares.
Horowitz DM, Furie RA.
Expert Opin Pharmacother. 2009 Jun;10(9):1501-7.

Or search the database yourself—it’s pretty easy. Enter “lupus trial” in the Search bar.

New Medical Therapies (NMT) Trial Results from Thomson CenterWatch
The database provides information about the results of recently completed and ongoing clinical trials. Select Systemic Lupus Erythematosus.

This information does not represent a Lupus Research Institute endorsement of any listed study. It is merely a notice that the study is available. If you are presently under the care of a physician for lupus or other conditions, you should not disrupt your current program without discussing it with your doctor(s). Do not contact the Lupus Research Institute for information on these studies. Only contact the listed numbers. The Lupus Research Institute does not have any jurisdiction over or further involvement with these studies, other than to make people aware that they are being conducted.