LRI-Funded Funded Study Points to Increased Risk for Lupus in Men

First Direct Evidence that X-Linked TLR7 Gene Promotes Lupus in Humans

Lupus Research Institute-funded researcher Betty Tsao, PhD, at the University of California Los Angeles has discovered that humans—males in particular—with a variant form of the immune receptor gene "Toll Like Receptor 7 (TLR7)" are at increased risk of developing the autoimmune disease systemic lupus erythematosus (lupus). This breakthrough finding offers renewed hope for developing more targeted treatments.

The powerful finding recently published in the Proceedings of the National Academy of Sciences (PNAS) represents additional strong evidence from human cells—as opposed to mice or other animal cells-that alterations in the TLR7 gene can promote lupus.